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Evolutionary Coupling Analysis

Predicted and experimental contacts

Interactive contact map

Secondary structure from ECs

Known pdb structures

pdb chain
2e50 A

EC score distribution and threshold

Top ECs

Rank Residue 1 Amino acid 1 Residue 2 Amino acid 2 EC score
1 268 D 274 E 0.48
2 262 D 266 D 0.45
3 268 D 272 E 0.41
4 269 E 275 D 0.40
5 205 W 218 G 0.37
6 267 E 271 E 0.35
7 271 E 275 D 0.35
8 248 D 253 E 0.35
9 190 A 197 E 0.34
10 269 E 273 D 0.34
11 243 G 247 E 0.34
12 270 G 275 D 0.34
13 201 S 206 F 0.34
14 267 E 275 D 0.33
15 200 E 204 T 0.31
16 257 G 261 I 0.31
17 224 D 232 Y 0.31
18 263 E 267 E 0.31
19 202 F 206 F 0.30
20 270 G 274 E 0.30
21 205 W 215 D 0.30
22 231 Q 236 P 0.30
23 266 D 272 E 0.29
24 254 E 258 L 0.29
25 265 G 269 E 0.29
26 193 K 197 E 0.29
27 265 G 275 D 0.28
28 255 E 259 E 0.28
29 251 D 264 E 0.28
30 205 W 226 W 0.27
31 168 S 209 H 0.27
32 254 E 264 E 0.27
33 205 W 229 P 0.27
34 264 E 268 D 0.27
35 230 L 234 L 0.26
36 214 A 235 V 0.26
37 247 E 252 D 0.26
38 218 G 225 I 0.26
39 204 T 209 H 0.26
40 215 D 224 D 0.26

Alignment robustness analysis

First most common residue correlation

Second most common residue correlation

Robustness